Binimetinib versus dacarbazine in patients with advanced NRAS-mutant melanoma (NEMO): a multicentre, open-label, randomised, phase 3 trial.
Identifieur interne : 001104 ( Main/Exploration ); précédent : 001103; suivant : 001105Binimetinib versus dacarbazine in patients with advanced NRAS-mutant melanoma (NEMO): a multicentre, open-label, randomised, phase 3 trial.
Auteurs : Reinhard Dummer [Suisse] ; Dirk Schadendorf [Allemagne] ; Paolo A. Ascierto [Italie] ; Ana Arance [Espagne] ; Caroline Dutriaux [France] ; Anna Maria Di Giacomo [Italie] ; Piotr Rutkowski [Pologne] ; Michele Del Vecchio [Italie] ; Ralf Gutzmer [Allemagne] ; Mario Mandala [Italie] ; Luc Thomas [France] ; Lev Demidov [Russie] ; Claus Garbe [Allemagne] ; David Hogg [Canada] ; Gabriella Liszkay [Hongrie] ; Paola Queirolo [Italie] ; Ernesto Wasserman [États-Unis] ; James Ford [États-Unis] ; Marine Weill [Suisse] ; L Andres Sirulnik [États-Unis] ; Valentine Jehl [Suisse] ; Viviana Boz N [États-Unis] ; Georgina V. Long [Australie] ; Keith Flaherty [États-Unis]Source :
- The Lancet. Oncology [ 1474-5488 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Benzimidazoles (administration et posologie), Dacarbazine (administration et posologie), Femelle, Humains, Mutation (génétique), Mâle, Mélanome (anatomopathologie), Mélanome (génétique), Mélanome (traitement médicamenteux), Pronostic, Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique), Protéines membranaires (génétique), Stade de la tumeur, Sujet âgé, Sujet âgé de 80 ans ou plus, Taux de survie, dGTPases (génétique), Études de suivi.
- MESH :
- administration et posologie : Benzimidazoles, Dacarbazine.
- anatomopathologie : Mélanome.
- génétique : Mutation, Mélanome, Protéines membranaires, dGTPases.
- traitement médicamenteux : Mélanome.
- usage thérapeutique : Protocoles de polychimiothérapie antinéoplasique.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Mâle, Pronostic, Stade de la tumeur, Sujet âgé, Sujet âgé de 80 ans ou plus, Taux de survie, Études de suivi.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Benzimidazoles (administration & dosage), Dacarbazine (administration & dosage), Female, Follow-Up Studies, GTP Phosphohydrolases (genetics), Humans, Male, Melanoma (drug therapy), Melanoma (genetics), Melanoma (pathology), Membrane Proteins (genetics), Middle Aged, Mutation (genetics), Neoplasm Staging, Prognosis, Survival Rate.
- MESH :
- chemical , administration & dosage : Benzimidazoles, Dacarbazine.
- chemical , genetics : GTP Phosphohydrolases, Membrane Proteins.
- drug therapy : Melanoma.
- genetics : Melanoma, Mutation.
- pathology : Melanoma.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols.
- Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasm Staging, Prognosis, Survival Rate.
Abstract
There are no established therapies specific for NRAS-mutant melanoma despite the emergence of immunotherapy. We aimed to assess the efficacy and safety of the MEK inhibitor binimetinib versus that of dacarbazine in patients with advanced NRAS-mutant melanoma.
DOI: 10.1016/S1470-2045(17)30180-8
PubMed: 28284557
Affiliations:
- Allemagne, Australie, Canada, Espagne, France, Hongrie, Italie, Pologne, Russie, Suisse, États-Unis
- Aquitaine, Bade-Wurtemberg, Basse-Saxe, Canton de Zurich, Catalogne, Colorado, District de Karlsruhe, District de Tübingen, District fédéral central, Hongrie centrale, Lombardie, Massachusetts, New Jersey, Nouvelle-Aquitaine, Nouvelle-Galles du Sud
- Barcelone, Bordeaux, Budapest, Hanovre, Heidelberg, Milan, Moscou, Sydney, Tübingen, Zurich
- Université de Sydney
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Le document en format XML
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Ascierto</name><affiliation wicri:level="1"><nlm:affiliation>Melanoma Unit, Cancer Immunotherapy and Innovative Therapies, Istituto Nazionale Tumori Fondazione Pascale, Via Mariano Semmola, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Melanoma Unit, Cancer Immunotherapy and Innovative Therapies, Istituto Nazionale Tumori Fondazione Pascale, Via Mariano Semmola, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Arance, Ana" sort="Arance, Ana" uniqKey="Arance A" first="Ana" last="Arance">Ana Arance</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Hospital Clinic of Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medical Oncology, Hospital Clinic of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Dutriaux, Caroline" sort="Dutriaux, Caroline" uniqKey="Dutriaux C" first="Caroline" last="Dutriaux">Caroline Dutriaux</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oncologic Dermatology, Centre Hospitalier Universitaire de Bordeaux, Hôpital Saint-André, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Oncologic Dermatology, Centre Hospitalier Universitaire de Bordeaux, Hôpital Saint-André, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Di Giacomo, Anna Maria" sort="Di Giacomo, Anna Maria" uniqKey="Di Giacomo A" first="Anna Maria" last="Di Giacomo">Anna Maria Di Giacomo</name><affiliation wicri:level="1"><nlm:affiliation>Medical Oncology and Immunotherapy, University Hospital of Siena, Viale Bracci, Siena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Medical Oncology and Immunotherapy, University Hospital of Siena, Viale Bracci, Siena</wicri:regionArea><wicri:noRegion>Siena</wicri:noRegion></affiliation></author><author><name sortKey="Rutkowski, Piotr" sort="Rutkowski, Piotr" uniqKey="Rutkowski P" first="Piotr" last="Rutkowski">Piotr Rutkowski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Del Vecchio, Michele" sort="Del Vecchio, Michele" uniqKey="Del Vecchio M" first="Michele" last="Del Vecchio">Michele Del Vecchio</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Giacomo Venezian, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Giacomo Venezian, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Gutzmer, Ralf" sort="Gutzmer, Ralf" uniqKey="Gutzmer R" first="Ralf" last="Gutzmer">Ralf Gutzmer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology and Allergy, Skin Cancer Center Hannover, Hannover Medical School, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology and Allergy, Skin Cancer Center Hannover, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Mandala, Mario" sort="Mandala, Mario" uniqKey="Mandala M" first="Mario" last="Mandala">Mario Mandala</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology and Haematology, Papa Giovanni XXIII Cancer Center Hospital, Bergamo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oncology and Haematology, Papa Giovanni XXIII Cancer Center Hospital, Bergamo</wicri:regionArea><wicri:noRegion>Bergamo</wicri:noRegion></affiliation></author><author><name sortKey="Thomas, Luc" sort="Thomas, Luc" uniqKey="Thomas L" first="Luc" last="Thomas">Luc Thomas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Centre Hospitalier Lyon Sud, Lyons Cancer Research Center, Lyon 1 University, Pierre Bénite, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Dermatology, Centre Hospitalier Lyon Sud, Lyons Cancer Research Center, Lyon 1 University, Pierre Bénite</wicri:regionArea><wicri:noRegion>Pierre Bénite</wicri:noRegion><wicri:noRegion>Pierre Bénite</wicri:noRegion></affiliation></author><author><name sortKey="Demidov, Lev" sort="Demidov, Lev" uniqKey="Demidov L" first="Lev" last="Demidov">Lev Demidov</name><affiliation wicri:level="3"><nlm:affiliation>N N Blokhin Russian Cancer Research Center, Ministry of Health, Moscow, Russian Federation.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>N N Blokhin Russian Cancer Research Center, Ministry of Health, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Garbe, Claus" sort="Garbe, Claus" uniqKey="Garbe C" first="Claus" last="Garbe">Claus Garbe</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, University Hospital Tuebingen, Tuebingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology, University Hospital Tuebingen, Tuebingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Hogg, David" sort="Hogg, David" uniqKey="Hogg D" first="David" last="Hogg">David Hogg</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University Health Network/Princess Margaret Hospital, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, University Health Network/Princess Margaret Hospital, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Liszkay, Gabriella" sort="Liszkay, Gabriella" uniqKey="Liszkay G" first="Gabriella" last="Liszkay">Gabriella Liszkay</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, National Institute of Oncology, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Dermatology, National Institute of Oncology, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Queirolo, Paola" sort="Queirolo, Paola" uniqKey="Queirolo P" first="Paola" last="Queirolo">Paola Queirolo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Institute for Cancer Research, IRCCS San Martino, Largo Rosanna Benzi, Genova, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Oncology, Institute for Cancer Research, IRCCS San Martino, Largo Rosanna Benzi, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Wasserman, Ernesto" sort="Wasserman, Ernesto" uniqKey="Wasserman E" first="Ernesto" last="Wasserman">Ernesto Wasserman</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Ford, James" sort="Ford, James" uniqKey="Ford J" first="James" last="Ford">James Ford</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Weill, Marine" sort="Weill, Marine" uniqKey="Weill M" first="Marine" last="Weill">Marine Weill</name><affiliation wicri:level="1"><nlm:affiliation>Novartis Pharma AG, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Novartis Pharma AG, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Sirulnik, L Andres" sort="Sirulnik, L Andres" uniqKey="Sirulnik L" first="L Andres" last="Sirulnik">L Andres Sirulnik</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Jehl, Valentine" sort="Jehl, Valentine" uniqKey="Jehl V" first="Valentine" last="Jehl">Valentine Jehl</name><affiliation wicri:level="1"><nlm:affiliation>Novartis Pharma AG, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Novartis Pharma AG, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Boz N, Viviana" sort="Boz N, Viviana" uniqKey="Boz N V" first="Viviana" last="Boz N">Viviana Boz N</name><affiliation wicri:level="2"><nlm:affiliation>Array BioPharma, Boulder, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Array BioPharma, Boulder, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Long, Georgina V" sort="Long, Georgina V" uniqKey="Long G" first="Georgina V" last="Long">Georgina V. Long</name><affiliation wicri:level="4"><nlm:affiliation>Melanoma Institute Australia, The University of Sydney, Royal North Shore and Mater Hospitals, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Melanoma Institute Australia, The University of Sydney, Royal North Shore and Mater Hospitals, Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Flaherty, Keith" sort="Flaherty, Keith" uniqKey="Flaherty K" first="Keith" last="Flaherty">Keith Flaherty</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medical Oncology, Massachusetts General Hospital, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Massachusetts General Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28284557</idno><idno type="pmid">28284557</idno><idno type="doi">10.1016/S1470-2045(17)30180-8</idno><idno type="wicri:Area/PubMed/Corpus">000E58</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E58</idno><idno type="wicri:Area/PubMed/Curation">000E55</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E55</idno><idno type="wicri:Area/PubMed/Checkpoint">000E55</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000E55</idno><idno type="wicri:Area/Ncbi/Merge">004450</idno><idno type="wicri:Area/Ncbi/Curation">004450</idno><idno type="wicri:Area/Ncbi/Checkpoint">004450</idno><idno type="wicri:Area/Main/Merge">001099</idno><idno type="wicri:Area/Main/Curation">001104</idno><idno type="wicri:Area/Main/Exploration">001104</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Binimetinib versus dacarbazine in patients with advanced NRAS-mutant melanoma (NEMO): a multicentre, open-label, randomised, phase 3 trial.</title><author><name sortKey="Dummer, Reinhard" sort="Dummer, Reinhard" uniqKey="Dummer R" first="Reinhard" last="Dummer">Reinhard Dummer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, University Hospital Zürich Skin Cancer Center, Zürich, Switzerland. Electronic address: reinhard.dummer@usz.ch.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Dermatology, University Hospital Zürich Skin Cancer Center, Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Schadendorf, Dirk" sort="Schadendorf, Dirk" uniqKey="Schadendorf D" first="Dirk" last="Schadendorf">Dirk Schadendorf</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, University Hospital Essen, Essen, Germany; German Cancer Consortium, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology, University Hospital Essen, Essen, Germany; German Cancer Consortium, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Ascierto, Paolo A" sort="Ascierto, Paolo A" uniqKey="Ascierto P" first="Paolo A" last="Ascierto">Paolo A. Ascierto</name><affiliation wicri:level="1"><nlm:affiliation>Melanoma Unit, Cancer Immunotherapy and Innovative Therapies, Istituto Nazionale Tumori Fondazione Pascale, Via Mariano Semmola, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Melanoma Unit, Cancer Immunotherapy and Innovative Therapies, Istituto Nazionale Tumori Fondazione Pascale, Via Mariano Semmola, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Arance, Ana" sort="Arance, Ana" uniqKey="Arance A" first="Ana" last="Arance">Ana Arance</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Hospital Clinic of Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medical Oncology, Hospital Clinic of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Dutriaux, Caroline" sort="Dutriaux, Caroline" uniqKey="Dutriaux C" first="Caroline" last="Dutriaux">Caroline Dutriaux</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oncologic Dermatology, Centre Hospitalier Universitaire de Bordeaux, Hôpital Saint-André, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Oncologic Dermatology, Centre Hospitalier Universitaire de Bordeaux, Hôpital Saint-André, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Di Giacomo, Anna Maria" sort="Di Giacomo, Anna Maria" uniqKey="Di Giacomo A" first="Anna Maria" last="Di Giacomo">Anna Maria Di Giacomo</name><affiliation wicri:level="1"><nlm:affiliation>Medical Oncology and Immunotherapy, University Hospital of Siena, Viale Bracci, Siena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Medical Oncology and Immunotherapy, University Hospital of Siena, Viale Bracci, Siena</wicri:regionArea><wicri:noRegion>Siena</wicri:noRegion></affiliation></author><author><name sortKey="Rutkowski, Piotr" sort="Rutkowski, Piotr" uniqKey="Rutkowski P" first="Piotr" last="Rutkowski">Piotr Rutkowski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Del Vecchio, Michele" sort="Del Vecchio, Michele" uniqKey="Del Vecchio M" first="Michele" last="Del Vecchio">Michele Del Vecchio</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Giacomo Venezian, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Giacomo Venezian, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Gutzmer, Ralf" sort="Gutzmer, Ralf" uniqKey="Gutzmer R" first="Ralf" last="Gutzmer">Ralf Gutzmer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology and Allergy, Skin Cancer Center Hannover, Hannover Medical School, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology and Allergy, Skin Cancer Center Hannover, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Mandala, Mario" sort="Mandala, Mario" uniqKey="Mandala M" first="Mario" last="Mandala">Mario Mandala</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology and Haematology, Papa Giovanni XXIII Cancer Center Hospital, Bergamo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oncology and Haematology, Papa Giovanni XXIII Cancer Center Hospital, Bergamo</wicri:regionArea><wicri:noRegion>Bergamo</wicri:noRegion></affiliation></author><author><name sortKey="Thomas, Luc" sort="Thomas, Luc" uniqKey="Thomas L" first="Luc" last="Thomas">Luc Thomas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Centre Hospitalier Lyon Sud, Lyons Cancer Research Center, Lyon 1 University, Pierre Bénite, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Dermatology, Centre Hospitalier Lyon Sud, Lyons Cancer Research Center, Lyon 1 University, Pierre Bénite</wicri:regionArea><wicri:noRegion>Pierre Bénite</wicri:noRegion><wicri:noRegion>Pierre Bénite</wicri:noRegion></affiliation></author><author><name sortKey="Demidov, Lev" sort="Demidov, Lev" uniqKey="Demidov L" first="Lev" last="Demidov">Lev Demidov</name><affiliation wicri:level="3"><nlm:affiliation>N N Blokhin Russian Cancer Research Center, Ministry of Health, Moscow, Russian Federation.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>N N Blokhin Russian Cancer Research Center, Ministry of Health, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Garbe, Claus" sort="Garbe, Claus" uniqKey="Garbe C" first="Claus" last="Garbe">Claus Garbe</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, University Hospital Tuebingen, Tuebingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology, University Hospital Tuebingen, Tuebingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Hogg, David" sort="Hogg, David" uniqKey="Hogg D" first="David" last="Hogg">David Hogg</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, University Health Network/Princess Margaret Hospital, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, University Health Network/Princess Margaret Hospital, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Liszkay, Gabriella" sort="Liszkay, Gabriella" uniqKey="Liszkay G" first="Gabriella" last="Liszkay">Gabriella Liszkay</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, National Institute of Oncology, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Dermatology, National Institute of Oncology, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Queirolo, Paola" sort="Queirolo, Paola" uniqKey="Queirolo P" first="Paola" last="Queirolo">Paola Queirolo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Institute for Cancer Research, IRCCS San Martino, Largo Rosanna Benzi, Genova, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Oncology, Institute for Cancer Research, IRCCS San Martino, Largo Rosanna Benzi, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Wasserman, Ernesto" sort="Wasserman, Ernesto" uniqKey="Wasserman E" first="Ernesto" last="Wasserman">Ernesto Wasserman</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Ford, James" sort="Ford, James" uniqKey="Ford J" first="James" last="Ford">James Ford</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Weill, Marine" sort="Weill, Marine" uniqKey="Weill M" first="Marine" last="Weill">Marine Weill</name><affiliation wicri:level="1"><nlm:affiliation>Novartis Pharma AG, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Novartis Pharma AG, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Sirulnik, L Andres" sort="Sirulnik, L Andres" uniqKey="Sirulnik L" first="L Andres" last="Sirulnik">L Andres Sirulnik</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Jehl, Valentine" sort="Jehl, Valentine" uniqKey="Jehl V" first="Valentine" last="Jehl">Valentine Jehl</name><affiliation wicri:level="1"><nlm:affiliation>Novartis Pharma AG, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Novartis Pharma AG, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Boz N, Viviana" sort="Boz N, Viviana" uniqKey="Boz N V" first="Viviana" last="Boz N">Viviana Boz N</name><affiliation wicri:level="2"><nlm:affiliation>Array BioPharma, Boulder, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Array BioPharma, Boulder, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Long, Georgina V" sort="Long, Georgina V" uniqKey="Long G" first="Georgina V" last="Long">Georgina V. Long</name><affiliation wicri:level="4"><nlm:affiliation>Melanoma Institute Australia, The University of Sydney, Royal North Shore and Mater Hospitals, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Melanoma Institute Australia, The University of Sydney, Royal North Shore and Mater Hospitals, Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Flaherty, Keith" sort="Flaherty, Keith" uniqKey="Flaherty K" first="Keith" last="Flaherty">Keith Flaherty</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medical Oncology, Massachusetts General Hospital, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Massachusetts General Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j">The Lancet. Oncology</title><idno type="eISSN">1474-5488</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Antineoplastic Combined Chemotherapy Protocols (therapeutic use)</term><term>Benzimidazoles (administration & dosage)</term><term>Dacarbazine (administration & dosage)</term><term>Female</term><term>Follow-Up Studies</term><term>GTP Phosphohydrolases (genetics)</term><term>Humans</term><term>Male</term><term>Melanoma (drug therapy)</term><term>Melanoma (genetics)</term><term>Melanoma (pathology)</term><term>Membrane Proteins (genetics)</term><term>Middle Aged</term><term>Mutation (genetics)</term><term>Neoplasm Staging</term><term>Prognosis</term><term>Survival Rate</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Benzimidazoles (administration et posologie)</term><term>Dacarbazine (administration et posologie)</term><term>Femelle</term><term>Humains</term><term>Mutation (génétique)</term><term>Mâle</term><term>Mélanome (anatomopathologie)</term><term>Mélanome (génétique)</term><term>Mélanome (traitement médicamenteux)</term><term>Pronostic</term><term>Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique)</term><term>Protéines membranaires (génétique)</term><term>Stade de la tumeur</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Taux de survie</term><term>dGTPases (génétique)</term><term>Études de suivi</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Benzimidazoles</term><term>Dacarbazine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>GTP Phosphohydrolases</term><term>Membrane Proteins</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Benzimidazoles</term><term>Dacarbazine</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Mélanome</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Melanoma</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Melanoma</term><term>Mutation</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Mutation</term><term>Mélanome</term><term>Protéines membranaires</term><term>dGTPases</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Melanoma</term></keywords><keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Mélanome</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Protocoles de polychimiothérapie antinéoplasique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neoplasm Staging</term><term>Prognosis</term><term>Survival Rate</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Pronostic</term><term>Stade de la tumeur</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Taux de survie</term><term>Études de suivi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There are no established therapies specific for NRAS-mutant melanoma despite the emergence of immunotherapy. We aimed to assess the efficacy and safety of the MEK inhibitor binimetinib versus that of dacarbazine in patients with advanced NRAS-mutant melanoma.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Espagne</li><li>France</li><li>Hongrie</li><li>Italie</li><li>Pologne</li><li>Russie</li><li>Suisse</li><li>États-Unis</li></country><region><li>Aquitaine</li><li>Bade-Wurtemberg</li><li>Basse-Saxe</li><li>Canton de Zurich</li><li>Catalogne</li><li>Colorado</li><li>District de Karlsruhe</li><li>District de Tübingen</li><li>District fédéral central</li><li>Hongrie centrale</li><li>Lombardie</li><li>Massachusetts</li><li>New Jersey</li><li>Nouvelle-Aquitaine</li><li>Nouvelle-Galles du Sud</li></region><settlement><li>Barcelone</li><li>Bordeaux</li><li>Budapest</li><li>Hanovre</li><li>Heidelberg</li><li>Milan</li><li>Moscou</li><li>Sydney</li><li>Tübingen</li><li>Zurich</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="Suisse"><region name="Canton de Zurich"><name sortKey="Dummer, Reinhard" sort="Dummer, Reinhard" uniqKey="Dummer R" first="Reinhard" last="Dummer">Reinhard Dummer</name></region><name sortKey="Jehl, Valentine" sort="Jehl, Valentine" uniqKey="Jehl V" first="Valentine" last="Jehl">Valentine Jehl</name><name sortKey="Weill, Marine" sort="Weill, Marine" uniqKey="Weill M" first="Marine" last="Weill">Marine Weill</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Schadendorf, Dirk" sort="Schadendorf, Dirk" uniqKey="Schadendorf D" first="Dirk" last="Schadendorf">Dirk Schadendorf</name></region><name sortKey="Garbe, Claus" sort="Garbe, Claus" uniqKey="Garbe C" first="Claus" last="Garbe">Claus Garbe</name><name sortKey="Gutzmer, Ralf" sort="Gutzmer, Ralf" uniqKey="Gutzmer R" first="Ralf" last="Gutzmer">Ralf Gutzmer</name></country><country name="Italie"><noRegion><name sortKey="Ascierto, Paolo A" sort="Ascierto, Paolo A" uniqKey="Ascierto P" first="Paolo A" last="Ascierto">Paolo A. Ascierto</name></noRegion><name sortKey="Del Vecchio, Michele" sort="Del Vecchio, Michele" uniqKey="Del Vecchio M" first="Michele" last="Del Vecchio">Michele Del Vecchio</name><name sortKey="Di Giacomo, Anna Maria" sort="Di Giacomo, Anna Maria" uniqKey="Di Giacomo A" first="Anna Maria" last="Di Giacomo">Anna Maria Di Giacomo</name><name sortKey="Mandala, Mario" sort="Mandala, Mario" uniqKey="Mandala M" first="Mario" last="Mandala">Mario Mandala</name><name sortKey="Queirolo, Paola" sort="Queirolo, Paola" uniqKey="Queirolo P" first="Paola" last="Queirolo">Paola Queirolo</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Arance, Ana" sort="Arance, Ana" uniqKey="Arance A" first="Ana" last="Arance">Ana Arance</name></region></country><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Dutriaux, Caroline" sort="Dutriaux, Caroline" uniqKey="Dutriaux C" first="Caroline" last="Dutriaux">Caroline Dutriaux</name></region><name sortKey="Thomas, Luc" sort="Thomas, Luc" uniqKey="Thomas L" first="Luc" last="Thomas">Luc Thomas</name></country><country name="Pologne"><noRegion><name sortKey="Rutkowski, Piotr" sort="Rutkowski, Piotr" uniqKey="Rutkowski P" first="Piotr" last="Rutkowski">Piotr Rutkowski</name></noRegion></country><country name="Russie"><region name="District fédéral central"><name sortKey="Demidov, Lev" sort="Demidov, Lev" uniqKey="Demidov L" first="Lev" last="Demidov">Lev Demidov</name></region></country><country name="Canada"><noRegion><name sortKey="Hogg, David" sort="Hogg, David" uniqKey="Hogg D" first="David" last="Hogg">David Hogg</name></noRegion></country><country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Liszkay, Gabriella" sort="Liszkay, Gabriella" uniqKey="Liszkay G" first="Gabriella" last="Liszkay">Gabriella Liszkay</name></region></country><country name="États-Unis"><region name="New Jersey"><name sortKey="Wasserman, Ernesto" sort="Wasserman, Ernesto" uniqKey="Wasserman E" first="Ernesto" last="Wasserman">Ernesto Wasserman</name></region><name sortKey="Boz N, Viviana" sort="Boz N, Viviana" uniqKey="Boz N V" first="Viviana" last="Boz N">Viviana Boz N</name><name sortKey="Flaherty, Keith" sort="Flaherty, Keith" uniqKey="Flaherty K" first="Keith" last="Flaherty">Keith Flaherty</name><name sortKey="Ford, James" sort="Ford, James" uniqKey="Ford J" first="James" last="Ford">James Ford</name><name sortKey="Sirulnik, L Andres" sort="Sirulnik, L Andres" uniqKey="Sirulnik L" first="L Andres" last="Sirulnik">L Andres Sirulnik</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Long, Georgina V" sort="Long, Georgina V" uniqKey="Long G" first="Georgina V" last="Long">Georgina V. Long</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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